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[Download] "Influence of Sampling-Time Error on Cyclosporine Measurements Nominally at 2 Hours After Administration (Technical Briefs)" by Clinical Chemistry # Book PDF Kindle ePub Free

Influence of Sampling-Time Error on Cyclosporine Measurements Nominally at 2 Hours After Administration (Technical Briefs)

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eBook details

  • Title: Influence of Sampling-Time Error on Cyclosporine Measurements Nominally at 2 Hours After Administration (Technical Briefs)
  • Author : Clinical Chemistry
  • Release Date : January 01, 2003
  • Genre: Chemistry,Books,Science & Nature,
  • Pages : * pages
  • Size : 181 KB

Description

Cyclosporine (CsA) blood concentrations measured 2 h after Neoral[R] administration ([c.sub.2]) are a sensitive predictor of clinical outcome in organ transplantation, as suggested by a recent prospective clinical trial in liver transplant patients (1). [c.sub.2] is now recommended as the target exposure index for the therapeutic drug monitoring (TDM) of CsA (2-8). The aim of this study was to investigate, for different types of grafts, the concentration-time relationships around [c.sub.2] to evaluate the concentration error as a function of the sampling-time error and to identify the sampling-time range compatible with acceptable performance of this [c.sub.2] TDM strategy. Data obtained from three different clinical trials were studied retrospectively. Each patient gave written informed consent, and each trial was approved by a local ethics committee (9-11). The three populations were as follows:


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